Tsalikakis D G, Fotiadis D I, Michalis L K, Kremmydas G P
Unit of Medical Technology and Intelligent Information Systems, Department of Computer Science, University of Ioannina, GR 45110 Ioannina, Greece.
IEEE Trans Biomed Eng. 2007 Sep;54(9):1710-4. doi: 10.1109/TBME.2007.902606.
In this paper, we use a one-dimensional model of the rabbit sinoatrial node (SAN), and we investigate the response of the model to hyperpolarizing and depolarizing stimulus. Depending on the stimulus timing, either a delay or an advance in the occurrence of next action potential is produced. This resetting behavior of the model is quantified in terms of phase transition curves (PTCs) for short electrical current pulses of varying amplitude which span the whole period. The main focus of this paper is to compare the dynamic properties of the spatially extended system and the single cell model. The detailed analysis of the results provides new insights in the understanding of the transition from the theoretical single cell models to the spatially extended systems.
在本文中，我们使用兔窦房结（SAN）的一维模型，并研究该模型对超极化和去极化刺激的响应。根据刺激时机，会产生下一个动作电位发生的延迟或提前。通过跨越整个周期的不同幅度的短电流脉冲的相变曲线（PTC）来量化该模型的这种重置行为。本文的主要重点是比较空间扩展系统和单细胞模型的动态特性。对结果的详细分析为理解从理论单细胞模型到空间扩展系统的转变提供了新的见解。
