Sontas B H, Ekici H
Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University, Avcilar Campus, 34850 Avcilar, Istanbul, Turkey.
Acta Vet Hung. 2007 Sep;55(3):379-87. doi: 10.1556/AVet.55.2007.3.12.
This study investigated the effects of ovariohysterectomy performed at 10 weeks of age on body weight, behaviour, bone length, serum calcium and phosphorus concentrations and gonadal hormone (progesterone and oestradiol) levels until 24 weeks of age in 31 clinically healthy mixed-breed female puppies. The littermates were randomly assigned to three groups. Group I (n=11) was completely ovariohysterectomised, Group II (n=10) was incompletely ovariohysterectomised with one ovary left intact, and Group III (n=10) was sham operated. No significant differences were found between the groups for any of the parameters evaluated. It was determined that, except for two measurements of two animals in Group II at 20 and 24 weeks of age, all animals had undetectable concentrations of oestradiol 17-beta. These findings suggest that an ovariohysterectomy performed on a mixed-breed dog at 10 weeks of age does not affect her skeletal, behavioural or physical development in the period studied, i.e. until 24 weeks of age.
本研究调查了31只临床健康的混种雌性幼犬在10周龄时进行卵巢子宫切除术对其体重、行为、骨骼长度、血清钙和磷浓度以及性腺激素（孕酮和雌二醇）水平的影响，直至24周龄。同窝幼犬被随机分为三组。第一组（n = 11）进行完全卵巢子宫切除术，第二组（n = 10）进行不完全卵巢子宫切除术，保留一个卵巢，第三组（n = 10）进行假手术。在评估的任何参数上，各组之间均未发现显著差异。确定除了第二组中两只动物在20周龄和24周龄时的两次测量外，所有动物的17-β雌二醇浓度均无法检测到。这些发现表明，10周龄的混种犬进行卵巢子宫切除术在所研究的时期（即直至24周龄）内不会影响其骨骼、行为或身体发育。
