Ali Sobia S, Ali Irum Sabir, Aamir A H, Jadoon Zahid, Inayatullah Saima
Department of Endocrinology, Hayatabad Medical Complex, Peshawar.
J Ayub Med Coll Abbottabad. 2007 Jan-Mar;19(1):46-9.
Diabetic patients are at an increased risk of acquiring Hepatitis C virus (HCV) infection owing to the nature of the disease and its inherent complications or frequent parentral exposure. On the other hand HCV infection may itself contribute to the development of Diabetes Mellitus. The epidemiological evidence of this association has not been studied in Pakistan at a population level and its exact biological mechanisms are not obvious. Objective of this study was to study the frequency of HCV infection among adult diabetic patients attending the Hospital.
The study comprised of 100 Diabetic patients visiting the out patient clinics or admitted in the medical wards of a Teaching Hospital, in Peshawar. Diabetes was confirmed according to the new diagnostic criteria based on 2 fasting or 2 random plasma glucose levels of more than 126 milligram per deciliter (mg/dL) and 200 mg/dL respectively. The presence of HCV infection was confirmed by Enzyme Linked Immuno-Sorbent Assay (ELISA) method. A concise history of the patient, examination and laboratory findings were recorded on a Performa.
Out of the hundred diabetics, 36% were found to be anti HCV positive and all of them had type II diabetes. There was no gender difference in the seropositive cases. Serum Glutamic-Pyruvic Transaminase (SGPT) level was raised in 75% of the positive cases as compared to the 25% of the seronegative patients. The seropositive cases had a comparatively higher blood sugar level.
HCV infection occurs more often in type II diabetics and further investigations should be done in diabetic patients with raised SGPT for the presence of chronic HCV infection.
由于糖尿病的性质及其固有并发症或频繁的肠道外暴露，糖尿病患者感染丙型肝炎病毒（HCV）的风险增加。另一方面，HCV感染本身可能促成糖尿病的发展。在巴基斯坦，尚未在人群层面研究这种关联的流行病学证据，其确切的生物学机制也不明确。本研究的目的是调查在该医院就诊的成年糖尿病患者中HCV感染的频率。
该研究包括100名在白沙瓦一家教学医院的门诊就诊或入住内科病房的糖尿病患者。根据新的诊断标准，基于两次空腹或两次随机血浆葡萄糖水平分别超过126毫克/分升（mg/dL）和200mg/dL来确诊糖尿病。通过酶联免疫吸附测定（ELISA）方法确认HCV感染的存在。在一份表格上记录患者的简要病史、检查和实验室检查结果。
在这100名糖尿病患者中，发现36%的患者抗HCV呈阳性，且所有这些患者均患有II型糖尿病。血清阳性病例中无性别差异。与25%的血清阴性患者相比，75%的阳性病例血清谷丙转氨酶（SGPT）水平升高。血清阳性病例的血糖水平相对较高。
HCV感染在II型糖尿病患者中更为常见，对于SGPT升高的糖尿病患者，应进一步检查是否存在慢性HCV感染。
