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[血型抗原在食管癌中的表达及其预后意义]

[Expression of blood group antigens(BGA) in esophageal carcinoma and its prognostic significance].

作者信息

Zhang H

机构信息

Department of the First Internal Medicine, Hebei Provincial, Hospital, Shijiazhang.

出版信息

Zhonghua Zhong Liu Za Zhi. 1991 May;13(3):165-7.

PMID:1786749
Abstract

Five monoclonal antibodies directed against BGA of ABH and Lewis systems and sensitive immunohistochemical SABC method were used to study the expression of these antigens and analyze its significance in prognosis. The results showed: 1. The normal esophageal mucosa in most cases expressed positive BGA; 2. BGA were deleted or lost in most esophageal carcinomas, and the incompatibility of antigens and precursor accumulation were also found. 3. Expression of three or more BGA simultaneously in the same specimen might indicate better prognosis than those which expressed less than two BGA. Incompatibility of antigens also had prognostic significance.

摘要

采用5种抗ABH和Lewis系统血型糖蛋白(BGA)的单克隆抗体及敏感的免疫组化SABC法,研究这些抗原的表达情况并分析其在预后中的意义。结果显示:1. 多数情况下正常食管黏膜BGA表达阳性;2. 多数食管癌中BGA缺失或丢失,且存在抗原不相容及前体物质蓄积现象;3. 同一标本中同时表达三种或以上BGA者较表达少于两种BGA者预后可能更好。抗原不相容也具有预后意义。

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