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[癌症研究中的有效数据收集:一体化数据库解决方案]

[Effective data collection in cancer research: an all-in-one database solution].

作者信息

Huszka C, Dahl E, Knüchel R, Donner A

机构信息

Institut für Pathologie, Universitätsklinikum Aachen.

出版信息

Verh Dtsch Ges Pathol. 2006;90:203-9.

Abstract

Tissue banks containing human malignant and benign tissue have become highly important for modem cancer research. They provide an excellent source of information with respect to pathological states and processes. Nowadays tissue samples can be examined using a broad variety of molecular biology methods, at the levels of DNA, RNA and protein. However, these new possibilities impose great expectations from the user side towards tissue banks and their associated databases. Nowadays a database that only manages tissue samples is not timely anymore. In fact a modern database should be capable of registering arbitraty amounts of tissue relevant information in an easily searchable way. In order to simplify the often complicated and time consuming process of data collection, we have developed a software solution that centralizes various aspects of tumor tissue banking. The main task of this software is not only to administer tissue samples but also to provide a centralized data platform for scientists which support their research. To achieve our goals we have constructed a tissue database which is supported by an Oracle System. The access to this database has been made possible with a light-weight, self-developed Java Client Program. The system possesses high levels of security and the access to information in the database is strictly controlled by preset permissions. A flexible search mechanism is also readily available for speedy data extraction according to various criteria. This solution provides us with an "All-in-one" tool for the purpose of flexible and efficient data collection and management in cancer research.

摘要

包含人类恶性和良性组织的组织库对于现代癌症研究已变得极为重要。它们提供了有关病理状态和过程的绝佳信息来源。如今,可以使用多种分子生物学方法在DNA、RNA和蛋白质水平上检查组织样本。然而,这些新的可能性使得用户对组织库及其相关数据库寄予了很高的期望。如今,一个仅管理组织样本的数据库已不再与时俱进。事实上,一个现代数据库应该能够以易于搜索的方式登记任意数量的与组织相关的信息。为了简化通常复杂且耗时的数据收集过程,我们开发了一种软件解决方案,该方案集中了肿瘤组织库的各个方面。该软件的主要任务不仅是管理组织样本,还为科学家提供一个支持他们研究的集中数据平台。为实现我们的目标,我们构建了一个由甲骨文系统支持的组织数据库。通过一个轻量级的、自行开发的Java客户端程序可以访问该数据库。该系统具有高度的安全性,对数据库中信息的访问由预设权限严格控制。还提供了一种灵活的搜索机制,以便根据各种标准快速提取数据。该解决方案为我们提供了一个“一体化”工具,用于在癌症研究中灵活高效地进行数据收集和管理。

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