冈田酸的自组装作为一种进入细胞的途径。

Self-assembly of okadaic acid as a pathway to the cell.

作者信息

Daranas Antonio Hernández, Cruz Patricia G, Creus Alberto Hernández, Norte Manuel, Fernández José J

机构信息

Instituto Universitario de Bio-OrgAnica Antonio GonzAlez, Astrofísico Francisco SAnchez 2, Universidad de La Laguna, 38206 La Laguna, Tenerife, Spain.

出版信息

Org Lett. 2007 Oct 11;9(21):4191-4. doi: 10.1021/ol701687m. Epub 2007 Sep 15.

DOI:10.1021/ol701687m

PMID:17867692

Abstract

The polyether toxin okadaic acid (OA) inhibits several protein serine/threonine phosphatases that play central roles in the regulation of many essential cellular processes. The use of scanning tunneling microscopy (STM) shows that dimerization of such toxins is crucial to understand the mechanism of toxin transport across model membranes.

摘要

聚醚毒素冈田酸（OA）可抑制多种蛋白质丝氨酸/苏氨酸磷酸酶，这些磷酸酶在调控许多重要细胞过程中发挥着核心作用。扫描隧道显微镜（STM）的应用表明，此类毒素的二聚化对于理解毒素跨模型膜转运的机制至关重要。