Aladyshev A V, Vorontsov V V
Farmakol Toksikol. 1991 Jul-Aug;54(4):33-5.
During in vitro and in situ experiments ethacrynic acid was shown to reduce the gastric secretion in rats, motility of the small intestine in rats and mice, contractions of the ileum of guinea pigs in response to histamine and acetylcholine. The intestinal water and electrolyte absorption in rats decreased too. All these effects of ethacrynic acid are extrarenal.
在体外和体内实验中,依他尼酸被证明可减少大鼠的胃液分泌、大鼠和小鼠的小肠蠕动,以及豚鼠回肠对组胺和乙酰胆碱的收缩反应。大鼠的肠道水和电解质吸收也减少。依他尼酸的所有这些作用均为肾外作用。