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[微粒体酶诱导剂对碘酰胺肾转运的影响]

[The effect of microsomal enzyme inducers on the renal transport of iodamide].

作者信息

Ul'ianov G P, Lampatov V V

出版信息

Farmakol Toksikol. 1991 Jul-Aug;54(4):35-7.

PMID:1786820
Abstract

On the 3rd day after the last administration of phenobarbital (50 mg/kg orally, 4 days), benzonal (35 mg/kg orally, 4 days), zixorine (200 mg/kg orally, 4 days) and 3-methylcholanthrene (20 mg/kg subcutaneously, 2 days) the rats exhibited a decrease of iodamide secretion in the kidneys. The administration of zixorine to the dog (200 mg orally, 6 days) led to a significant decrease of iodamide transport in the first two weeks after discontinuation of the drug administration.

摘要

在最后一次给予苯巴比妥(口服50毫克/千克,共4天)、苯唑那尔(口服35毫克/千克,共4天)、紫罗碱(口服200毫克/千克,共4天)和3 - 甲基胆蒽(皮下注射20毫克/千克,共2天)后的第3天,大鼠肾脏中的碘酰胺分泌减少。给狗服用紫罗碱(口服200毫克,共6天)导致在停药后的前两周碘酰胺转运显著减少。

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