Khlopushina T G, Krinskaia A V
Farmakol Toksikol. 1991 Jul-Aug;54(4):39-41.
The effect of adamanthylamides of 1,3-diphenylptrazol-4-carbonic acids on the system of the liver microsomal monoxygenases was studied. A potent induction of the liver cytochrome P-450 by 1,3-diphenylpyrazol-5-methyl-4-carbonic acid, N-methyl-N-(adamant-1-il)amide was found. As a consequence of the induction of the liver cytochrome P-450, the compound reduced by 40% the degree of the delayed type hypersensitivity in mice.
研究了1,3 - 二苯基吡唑 - 4 - 碳酸的金刚烷基酰胺对肝脏微粒体单加氧酶系统的影响。发现1,3 - 二苯基吡唑 - 5 - 甲基 - 4 - 碳酸N - 甲基 - N -（金刚烷 - 1 - 基）酰胺对肝脏细胞色素P - 450有强烈诱导作用。由于肝脏细胞色素P - 450的诱导，该化合物使小鼠迟发型超敏反应程度降低了40%。
