[血小板活化因子结构类似物的抗炎活性]
[The anti-inflammatory activity of structural analogs of the platelet-activating factor].
作者信息
Melikiants A G, Kulikov V I, Koloskova E E, Kuznetsova T I, Dergousov A A, Lipatkina L Iu
出版信息
Farmakol Toksikol. 1991 Jul-Aug;54(4):43-5.
PMID:1786825
Abstract
The pro- and anti-inflammatory activity of new structural analogues of the platelet-activating factor (PAF) was studied. It was found that three PAF analogues inhibit PAF-induced rat paw edema in a dose-dependent manner. The anti-inflammatory activity of one of the PAF analogues upon PAF- or carrageenan-induced inflammation was comparable or in some extent exceeded that of dexamethasone.
摘要
研究了血小板活化因子（PAF）新结构类似物的促炎和抗炎活性。发现三种PAF类似物以剂量依赖性方式抑制PAF诱导的大鼠爪肿胀。其中一种PAF类似物对PAF或角叉菜胶诱导的炎症的抗炎活性与地塞米松相当，或在某种程度上超过了地塞米松。
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