Napolov Iu K, Borisov K B
Farmakol Toksikol. 1991 Jul-Aug;54(4):80-7.
The data on immunodepressants most commonly used in the Soviet Union in the diseases caused by disorders in normal function of the immune system are presented. Such drugs as cyclosporine A, cyclophosphan, azatioprine, 6-mercaptopurine are considered. Emphasis is given to the mechanism of the primary pharmacological response of the drugs to the immunocompetent cells, the grounding of their clinical use, dosage and mechanisms of possible side effects.
本文介绍了苏联最常用于因免疫系统正常功能紊乱引起疾病的免疫抑制剂的数据。文中考虑了环孢素A、环磷酰胺、硫唑嘌呤、6-巯基嘌呤等药物。重点阐述了这些药物对免疫活性细胞的主要药理反应机制、临床应用依据、剂量及可能的副作用机制。
