[糖尿病肾病：肾小球滤过率与估算的肌酐清除率]
[Diabetic nephropathy: glomerular filtration rate and estimated creatinine clearance].
作者信息
Guimarães Joana, Bastos Margarida, Melo Miguel, Carvalheiro Manuela
机构信息
Serviço Endocrinologia, Diabetes e Metabolismo, Hospitais da Universidade de Coimbra, Coimbra.
出版信息
Acta Med Port. 2007 Mar-Apr;20(2):145-50. Epub 2007 Jun 11.
OBJECTIVE
To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR).
PATIENTS AND METHODS
We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes.
RESULTS
There was a strong positive correlation between the two methods but the Cockroft Gault formula underestimated the GFR.
CONCLUSIONS
The formula gives a accurate estimates of GFR, when GFR is <100 ml/min/1,73 m2. Beside the underestimation, the formula could be used in the management of diabetic nephropathy because the repeated isotope assessments of renal function are impracticable.
目的
在糖尿病肾病中，评估估算肌酐清除率（用 Cockcroft Gault 公式计算）及锝 99m -二乙三胺五乙酸（Tc99m - DTPA）清除率用于测量肾小球滤过率（GFR）的准确性。
患者与方法
我们分析了 21 例 1 型或 2 型糖尿病患者通过 Tc99m - DTPA 法测量的 GFR 以及用 Cockcroft Gault 公式估算的 GFR。
结果
两种方法之间存在强正相关，但 Cockcroft Gault 公式低估了 GFR。
结论
当 GFR <100 ml/min/1.73 m²时，该公式能准确估算 GFR。除了低估这一情况外，该公式可用于糖尿病肾病的管理，因为对肾功能进行反复的同位素评估不切实际。
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