Sokol Deborah K, O'Brien Roderick S, Wagenknecht Dawn R, Rao Thota, McIntyre John A
Indiana University School of Medicine, Department of Neurology 575 West Drive-XE 40 Indianapolis, IN 46202, USA.
J Neuroimmunol. 2007 Oct;190(1-2):151-6. doi: 10.1016/j.jneuroim.2007.08.002. Epub 2007 Sep 14.
Antiphospholipid antibodies (aPL) have been reported in the cerebrospinal fluids (CSF) of neurology patients but no CSF studies with psychiatric patients exist. We tested serum from 100 hospitalized psychotic patients having hallucinations and/or delusions for aPL. Patients with positive serum aPL findings were asked to submit CSF for aPL testing. Five CSF samples had aPL specificities not found in the patient's serum suggesting the possibility of intrathecal synthesis. Specificity and isotype discordance between CSF and blood aPL in these psychiatric patients implicates a central nervous system independent autoimmune process that may have an underlying association with the pathophysiology of their diseases.
抗磷脂抗体（aPL）已在神经病学患者的脑脊液（CSF）中被报道，但尚无针对精神病患者的脑脊液研究。我们检测了100名因幻觉和/或妄想而住院的精神病患者血清中的aPL。血清aPL检测结果呈阳性的患者被要求提交脑脊液进行aPL检测。5份脑脊液样本具有患者血清中未发现的aPL特异性，提示存在鞘内合成的可能性。这些精神病患者脑脊液和血液中aPL之间的特异性和同种型不一致表明存在中枢神经系统独立的自身免疫过程，这可能与其疾病的病理生理学存在潜在关联。
