Schott K, Batra A, Richartz E, Sarkar R, Günthner A, Bartels M, Buchkremer G
Universitätsklinik für Psychiatrie und Psychotherapie, Tübingen, Federal Republic of Germany.
J Neural Transm (Vienna). 1998;105(4-5):517-24. doi: 10.1007/s007020050075.
Antibody reactivity in serum to synaptic membranes from human was investigated in major depressive disorder (N = 20), paranoid schizophrenia (N = 20), schizoaffective psychosis (N = 20), and in controls (N = 20) using Western and Immunoblots and ELISA technique. None of the patients showed a significant immune response to synaptic membranes. There was a base-line activity in both controls and patients with antibodies directed to a double band of proteins at 66kD. These antibodies may represent natural autoantibodies. The authors conclude from this and other studies that there is at present no proof of antibrain antibodies in mental disorder.
利用蛋白质免疫印迹法和酶联免疫吸附测定技术，对20名重度抑郁症患者、20名偏执型精神分裂症患者、20名分裂情感性精神病患者以及20名对照者血清中针对人突触膜的抗体反应性进行了研究。没有一名患者对突触膜表现出显著的免疫反应。在对照者和患者中均存在针对66kD双条带蛋白的抗体基线活性。这些抗体可能代表天然自身抗体。作者基于此项研究及其他研究得出结论，目前尚无证据表明精神障碍患者体内存在抗脑抗体。
