Dohi Kenji, Ripley Beth, Fujiki Nobuhiro, Ohtaki Hirokazu, Yamamoto Takefumi, Goto Yoko, Nakamachi Tomoya, Shioda Seiji, Aruga Tohru, Nishino Seiji
Showa University, Department of Emergency and Critical Care Medicine, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.
Regul Pept. 2008 Jan 10;145(1-3):60-4. doi: 10.1016/j.regpep.2007.08.005. Epub 2007 Aug 22.
Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of both the feeding behavior neuroendocrine functions and sleep-wakefulness cycle. Recent studies have suggested that the orexin system may also be involved in neuronal damage in the clinical setting and animal experiments. The aim of this study was to examine the role of the hypothalamic orexin-A/hypocretin-1 system in patients with intracerebral hemorrhage (ICH). The CSF orexin-A/hypocretin-1 levels were measured in 11 ICH patients. CSF orexin-A/hypocretin-1 levels were low in ICH patients during the 13 days following the ICH event. The mean CSF orexin-A/hypocretin-1 levels were 61.1+/-22.3 (S.D.) pg/ml (range 27.5-106.9 pg/ml). The decreasing in the CSF orexin-A/hypocretin-1 levels was not related to the severity of ICH. The CSF orexin-A/hypocretin-1 levels were lower in the thalamic hemorrhage patients than those in other patients (48.5+/-23.3 pg/ml vs. 65.2+/-21.2 pg/ml; p=0.03.) These data indicate that orexin-A/hypocretin-1 may therefore play an important role in the various physiological responses including sleep, feeding, and the overall metabolism in ICH patients.
食欲素/下丘脑泌素是具有多种生理作用的神经肽，包括对摄食行为、神经内分泌功能以及睡眠-觉醒周期的调节。最近的研究表明，在临床环境和动物实验中，食欲素系统可能也与神经元损伤有关。本研究的目的是探讨下丘脑食欲素-A/下丘脑泌素-1系统在脑出血（ICH）患者中的作用。对11例ICH患者的脑脊液食欲素-A/下丘脑泌素-1水平进行了测定。ICH事件发生后的13天内，ICH患者的脑脊液食欲素-A/下丘脑泌素-1水平较低。脑脊液食欲素-A/下丘脑泌素-1的平均水平为61.1±22.3（标准差）pg/ml（范围为27.5 - 106.9 pg/ml）。脑脊液食欲素-A/下丘脑泌素-1水平的降低与ICH的严重程度无关。丘脑出血患者的脑脊液食欲素-A/下丘脑泌素-1水平低于其他患者（48.5±23.3 pg/ml对65.2±21.2 pg/ml；p = 0.03）。这些数据表明，食欲素-A/下丘脑泌素-1可能因此在ICH患者的包括睡眠、摄食和整体代谢在内的各种生理反应中发挥重要作用。
