Liao Hui-Ling, Chen Jin-Tang, Ma Tso-Chiang, Chang Yuan-Shiun
Institute of Chinese Pharmaceutical Sciences, China Medical University, 91 Hsueh Shih Road, Taichung 40402, Taiwan.
Arch Gerontol Geriatr. 2008 Jul-Aug;47(1):99-107. doi: 10.1016/j.archger.2007.06.007. Epub 2007 Sep 14.
With the progressive aging of the population, the long-term nursing care and drug safety for the elderly are gradually gaining attention. In Taiwan, nursing homes are the main institutes helping society or families take care of elderly people suffering from diseases. The aim of this study was to assess the prescribed medications of nursing home residents, the occurrence of DDIs and the association between the number of drugs and DDIs with a view to reinforce drug safety for the elderly. The findings of this study showed that the mean number of medications per resident was 5.74+/-2.4. Of the 323 samples, 81 (25.1%) had experienced DDIs, 63 (64.95%) were of moderate and 7 (7.2%) of major severity. The findings also showed that the number of potential DDIs increased as the number of medications used per residents increased. The residents with nine or more medications tended to have more DDIs, in comparison to those with one or two medications. The odds ratio (OR) was 11.389, which had reached statistical significance in difference. Therefore, to reduce potential DDIs, the number of medications for the senior people with chronic diseases should be properly controlled.
随着人口的逐步老龄化，老年人的长期护理和用药安全逐渐受到关注。在台湾，养老院是帮助社会或家庭照顾患病老年人的主要机构。本研究的目的是评估养老院居民的处方药使用情况、药物相互作用（DDIs）的发生情况以及药物数量与DDIs之间的关联，以加强老年人的用药安全。本研究结果显示，每位居民的平均用药数量为5.74±2.4。在323个样本中，81例（25.1%）发生了药物相互作用，其中63例（64.95%）为中度，7例（7.2%）为重度。研究结果还表明，随着每位居民用药数量的增加，潜在药物相互作用的数量也会增加。与使用一两种药物的居民相比，使用九种或更多药物的居民往往有更多的药物相互作用。优势比（OR）为11.389，差异具有统计学意义。因此，为减少潜在的药物相互作用，应适当控制患有慢性病的老年人的用药数量。
