Hagens Werner I, Oomen Agnes G, de Jong Wim H, Cassee Flemming R, Sips Adriënne J A M
Centre for Substances and Integrated Risk Assessment (SIR), National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.
Regul Toxicol Pharmacol. 2007 Dec;49(3):217-29. doi: 10.1016/j.yrtph.2007.07.006. Epub 2007 Aug 15.
Nowadays the development and applications of nanotechnology are of major importance in both industrial and consumer areas. However, the knowledge on human exposure and possible toxicity of nanotechnology products is limited. To understand the mechanism of toxicity, thorough knowledge of the toxicokinetic properties of nanoparticles is warranted. There is a need for information on the absorption, distribution, metabolism and excretion (ADME) of nanoparticles and validated detection methods of these man-made nanoparticles. Determination of the ADME properties of nanoparticles requires specialised detection methods in different biological matrices (e.g. blood and organs). In this paper, the current knowledge on the kinetic properties of nanoparticles is reviewed. Moreover, knowledge gaps from a kinetic point of view (detection, dose, ADME processes) are identified.
如今，纳米技术的发展与应用在工业和消费领域都至关重要。然而，关于人类接触纳米技术产品及其可能的毒性的知识却很有限。为了解毒性机制，有必要深入了解纳米颗粒的毒代动力学特性。需要有关纳米颗粒吸收、分布、代谢和排泄（ADME）的信息以及这些人造纳米颗粒的有效检测方法。测定纳米颗粒的ADME特性需要在不同生物基质（如血液和器官）中采用专门的检测方法。本文对纳米颗粒动力学特性的现有知识进行了综述。此外，还从动力学角度（检测、剂量、ADME过程）识别了知识空白。
