Tsang W Y, Chan J K, Fletcher C D
Institute of Pathology, Queen Elizabeth Hospital, Hong Kong.
Histopathology. 1991 Dec;19(6):489-501. doi: 10.1111/j.1365-2559.1991.tb01497.x.
This review summarizes the clinicopathological features of a number of vascular tumours that have been characterized only in recent years. These include: glomeruloid haemangioma, a multifocal vascular lesion associated with POEMS syndrome: Kaposi-like infantile haemangioendothelioma, a borderline malignant tumour occurring in the retroperitoneum of infants, mimicking Kaposi's sarcoma histologically; giant cell angioblastoma, characterized by proliferated vessels with a granuloma-like appearance; benign lymphangioendothelioma (progressive lymphangioma), slowly-growing macule or plaque over the trunk or limb, mimicking low-grade angiosarcoma histologically; targetoid haemosiderotic haemangioma, a benign lesion with a distinctive annular appearance and histologically overlapping with benign lymphangioendothelioma; spindle cell haemangioendothelioma, a lesion located mostly in the distal extremities, characterized by cavernous vascular spaces, spindle cells with interspersed narrow vascular channels and scattered plump vacuolated endothelial cells; acquired tufted angioma, characterized by 'cannon-ball' involvement of the dermis by lobules of pericyte-rich capillaries; sinusoidal haemangioma, a distinctive variant of cavernous haemangioma which may be confused with angiosarcoma; and epithelioid angiosarcoma, a highly aggressive tumour of deep soft tissue mimicking metastatic carcinoma and co-expressing endothelial and epithelial markers.
本综述总结了一些近年来才得以明确特征的血管肿瘤的临床病理特征。这些肿瘤包括:肾小球样血管瘤,一种与POEMS综合征相关的多灶性血管病变;卡波西样婴儿血管内皮瘤,一种发生于婴儿腹膜后的交界性恶性肿瘤,组织学上类似卡波西肉瘤;巨细胞血管母细胞瘤,其特征为血管增生,呈肉芽肿样外观;良性淋巴管内皮瘤(进行性淋巴管瘤),躯干或肢体上缓慢生长的斑疹或斑块,组织学上类似低级别血管肉瘤;靶样含铁血黄素性血管瘤,一种具有独特环状外观的良性病变,组织学上与良性淋巴管内皮瘤有重叠;梭形细胞血管内皮瘤,一种主要位于四肢远端的病变,其特征为海绵状血管腔隙、散在狭窄血管通道的梭形细胞以及散在的丰满空泡状内皮细胞;获得性丛状血管瘤,其特征为富含周细胞的毛细血管小叶呈“炮弹”样累及真皮;窦状血管瘤,海绵状血管瘤的一种独特变体,可能与血管肉瘤混淆;以及上皮样血管肉瘤,一种发生于深部软组织的高侵袭性肿瘤,类似转移性癌,同时表达内皮和上皮标志物。