利用植物表达的药物对抗癌症。

Fighting cancer with plant-expressed pharmaceuticals.

作者信息

Pujol Merardo, Gavilondo Jorge, Ayala Marta, Rodríguez Meilyn, González Ernesto M, Pérez Lincidio

机构信息

Plant Division, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, C.P. 10600, Havana, Cuba.

出版信息

Trends Biotechnol. 2007 Oct;25(10):455-9. doi: 10.1016/j.tibtech.2007.09.001. Epub 2007 Sep 14.

DOI:10.1016/j.tibtech.2007.09.001

PMID:17869360

Abstract

Cancer is one of the most prevalent diseases worldwide, which explains why biological therapies for cancer are forecast to make up 35% of total recombinant pharmaceuticals by 2010. Because of the high demand for cancer drugs, the need to lower production costs and the constraints of present production technologies for recombinant pharmaceuticals (such as the difficulties involved in culturing bacteria, yeast and mammalian cells), attention has recently been focused on recombinant expression of pharmaceutical anti-cancer proteins in plants. This review aims to provide an update on the most recent publications about anti-cancer recombinant pharmaceuticals expressed in plants, as well as on the relevant technical issues, potential and prospects of this emerging production system.

摘要

癌症是全球最普遍的疾病之一，这也解释了为何预计到2010年癌症生物疗法将占重组药物总量的35%。由于对癌症药物的高需求、降低生产成本的需要以及目前重组药物生产技术的限制（如培养细菌、酵母和哺乳动物细胞所涉及的困难），近来人们的注意力集中在植物中药物抗癌蛋白的重组表达上。这篇综述旨在提供有关植物中表达的抗癌重组药物的最新出版物的最新情况，以及这个新兴生产系统的相关技术问题、潜力和前景。