McCarthy Patrick M
Bluhm Cardiovascular Institute, Division of Cardiothoracic Surgery, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611-2908, USA.
Semin Thorac Cardiovasc Surg. 2007 Summer;19(2):121-6. doi: 10.1053/j.semtcvs.2007.06.002.
Tricuspid regurgitation (TR) and atrial fibrillation (AF) are frequently encountered in patients with myxomatous mitral valve disease. Recent publications have indicated the seriousness of untreated TR, even in those with no TR but only annular dilation. If left untreated, the patients with annular dilation without TR were more prone to develop TR during follow-up and had worse New York Heart Association functional class. At the Bluhm Cardiovascular Institute, 39% of patients who had mitral valve surgery had a history of AF. This included 54.4% of patients who were undergoing a re-operation. Five randomized, prospective clinical trials have documented that patients with permanent AF who undergo mitral valve surgery are far more likely to return to sinus rhythm if AF is treated with ablation at the same time as the mitral valve operation. For the group of patients with permanent AF, sinus rhythm was restored in only 5% to 33% of patients in the control group versus 44% to 93% of those in whom ablation was applied. A variety of technologies are available to ablate AF. The basic lesion must electrically isolate the pulmonary veins. For patients with permanent AF, there is evidence that a connecting lesion to the mitral valve annulus will increase success and that biatrial lesion sets will provide the best long-term freedom from AF.
三尖瓣反流(TR)和心房颤动(AF)在黏液瘤样二尖瓣疾病患者中经常出现。最近的出版物表明,未经治疗的TR很严重,即使是那些没有TR但仅有瓣环扩张的患者也是如此。如果不进行治疗,没有TR但有瓣环扩张的患者在随访期间更容易发生TR,且纽约心脏协会功能分级更差。在布卢姆心血管研究所,接受二尖瓣手术的患者中有39%有房颤病史。这包括54.4%正在接受再次手术的患者。五项随机、前瞻性临床试验证明,接受二尖瓣手术的永久性房颤患者如果在二尖瓣手术同时进行消融治疗房颤,恢复窦性心律的可能性要大得多。对于永久性房颤患者组,对照组中只有5%至33%的患者恢复了窦性心律,而接受消融治疗的患者中这一比例为44%至93%。有多种技术可用于消融房颤。基本病变必须电隔离肺静脉。对于永久性房颤患者,有证据表明与二尖瓣环的连接性病变会提高成功率,双心房病变组将提供最佳的长期无房颤状态。