Jia Honglin, Terkawi M Alaa, Aboge Gabriel Oluga, Goo Youn-Kyoung, Zhou Jinlin, Lee Eung-Goo, Nishikawa Yoshifumi, Igarashi Ikuo, Fujisaki Kozo, Xuan Xuenan
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
Exp Parasitol. 2008 Jan;118(1):146-9. doi: 10.1016/j.exppara.2007.07.005. Epub 2007 Aug 3.
In this report, an immunodominant antigen called BgIRA from Babesia gibsoni is identified and described. A highly repetitive antigen was screened from a cDNA library. The genomic BgIRA gene exists as single cope gene and contains 10 introns. BgIRA plays a dominant role in the immune response in dogs infected with B. gibsoni. The specificity and sensitivity of the rBgIRA in an ELISA indicated that this antigen might be useful in a diagnostic test.
在本报告中，一种名为BgIRA的来自吉氏巴贝斯虫的免疫显性抗原被鉴定和描述。从一个cDNA文库中筛选出一种高度重复的抗原。基因组BgIRA基因以单拷贝基因形式存在，包含10个内含子。BgIRA在感染吉氏巴贝斯虫的犬类免疫反应中起主导作用。ELISA中重组BgIRA的特异性和敏感性表明该抗原可能在诊断试验中有用。
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