Lee Jae-Hoon, Choi Chi-Bong, Chung Dai-Jung, Kang Eun-Hee, Chang Hwa-Seok, Hwang Soo-Han, Han Hoon, Choe Bo-Young, Sur Jung-Hyang, Lee Soo-Yeol, Kim Hwi-Yool
Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, #1 Hwayang-Dong, Kwangjin-Gu, Seoul 143-701, Republic of Korea.
J Neurosci Methods. 2008 Jan 30;167(2):310-6. doi: 10.1016/j.jneumeth.2007.07.020. Epub 2007 Aug 7.
We developed a minimally invasive canine model of spinal cord injury (SCI). A balloon catheter was inserted into the epidural space via the lumbosacral space, and inflated between L2 and L3 for 30 or 60 min under fluoroscopic guidance. Motor function after SCI was assessed using modified Tarlov scale. All seven dogs showed complete paraplegia after the procedure, neurological problems were evident and the modified Tarlov scores remained at zero after the SCI procedure; no improvement in clinical signs was observed. The dogs underwent 3T MR imaging at 3 days and 1 year after SCI. Histopathologic examinations were conducted at 2 weeks, 12 weeks and 1 year after SCI. In the present study, we described an animal model of minimally invasive spinal cord injury using a balloon catheter without laminectomy under fluoroscopic guidance. And, this percutaneous spinal cord compression injury model has many potential applications. The described percutaneous spinal cord compression injury model offers a new means of administering SCI and has many potential applications.
我们建立了一种微创犬脊髓损伤（SCI）模型。通过腰骶间隙将球囊导管插入硬膜外间隙，并在透视引导下于L2和L3之间充气30或60分钟。使用改良的Tarlov量表评估脊髓损伤后的运动功能。所有7只犬在手术后均出现完全性截瘫，神经问题明显，脊髓损伤手术后改良的Tarlov评分仍为零；未观察到临床体征改善。这些犬在脊髓损伤后3天和1年接受了3T磁共振成像检查。在脊髓损伤后2周、12周和1年进行组织病理学检查。在本研究中，我们描述了一种在透视引导下使用球囊导管且无需椎板切除术的微创脊髓损伤动物模型。并且，这种经皮脊髓压迫损伤模型有许多潜在应用。所描述的经皮脊髓压迫损伤模型提供了一种实施脊髓损伤的新方法，并有许多潜在应用。
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