Mimetics of the tri- and tetrasaccharide epitope of GQ1balpha as myelin-associated glycoprotein (MAG) ligands.
作者信息
Gao Ganpan, Smiesko Martin, Schwardt Oliver, Gäthje Heiko, Kelm Soerge, Vedani Angelo, Ernst Beat
机构信息
Institute of Molecular Pharmacy, Pharmacenter, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
出版信息
Bioorg Med Chem. 2007 Dec 1;15(23):7459-69. doi: 10.1016/j.bmc.2007.07.033. Epub 2007 Aug 21.
PMID:17870542
Abstract
The synthesis of phenoxyphenyl, phenoxybenzyl, biphenyl, and phenyltriazole substituted sialic acid derivatives as mimics of the tri- and tetrasaccharide epitopes of GQ1balpha is described. These synthetically easily available sialosides show comparable or even enhanced affinity to MAG compared with the natural tri- and tetrasaccharide epitopes and form a new class of potential MAG antagonists.
摘要
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