放射性标记白蛋白微球的研制：碘（¹³¹I）和铟（¹¹¹In/¹¹³mIn）发射γ射线的放射性同位素的比较。

Development of radiolabelled albumin microspheres: a comparison of gamma-emitting radioisotopes of iodine (131I) and indium (111In/113mIn).

作者信息

Willmott N, Murray T, Carlton R, Chen Y, Logan H, McCurrach G, Bessent R G, Goldberg J A, Anderson J, McKillop J H

机构信息

Department of Pharmacy, University of Strathclyde, Glasgow, Scotland.

出版信息

Int J Rad Appl Instrum B. 1991;18(7):687-94. doi: 10.1016/0883-2897(91)90006-7.

DOI:10.1016/0883-2897(91)90006-7

Abstract

Biodegradable albumin microspheres have been prepared incorporating either 131I or 111In/111In. Using cDTPAA/albumin molar ratios of 1, 3 and 10, approx. 0.7, 2.1 and 7 molecules of DTPA could be coupled to an albumin molecule, labelling efficiency being constant over this range. Because 131I microspheres were more stable in plasma than the system labelled with radionuclides of indium it was selected for clinical evaluation: potential uses of this radiopharmaceutical are illustrated.

摘要

已制备出包含131I或111In/111In的可生物降解白蛋白微球。使用1、3和10的cDTPAA/白蛋白摩尔比，大约0.7、2.1和7个二乙三胺五乙酸（DTPA）分子可与一个白蛋白分子偶联，在此范围内标记效率保持恒定。由于131I微球在血浆中比用铟放射性核素标记的系统更稳定，因此被选用于临床评估：文中阐述了这种放射性药物的潜在用途。

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