Hb Cleveland or alpha 2 beta 2(93)(F9)Cys----Arg;121(GH4)Glu----Gln.

作者信息

Wilson J B, Ramachandran M, Webber B B, Kutlar F, Hazelwood L F, Barnett D, Hirschler N V, Huisman T H

机构信息

Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.

出版信息

Hemoglobin. 1991;15(4):269-78. doi: 10.3109/03630269109027879.

Hb Cleveland is characterized by two amino acid substitutions, namely beta 121(GH4)Glu----Gln as in Hb D-Los Angeles and beta 93(F9)Cys----Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th beta chain variant with two substitutions that has been described thus far.