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[《鼻鼻窦结局测试-20德语改编版(SNOT-20 GAV)评分量表的制定》]

[Development of a grading scale for the Sino-Nasal Outcome Test-20 German Adapted Version (SNOT-20 GAV)].

作者信息

Baumann I, Plinkert P K, De Maddalena H

机构信息

Universitäts-HNO-Klinik, Im Neuenheimer Feld 400, 69120 Heidelberg.

出版信息

HNO. 2008 Aug;56(8):784-8. doi: 10.1007/s00106-007-1606-9.

DOI:10.1007/s00106-007-1606-9
PMID:17874055
Abstract

INTRODUCTION

Quality of life measurements with the Sino-Nasal Outcome Test-20 German Adapted Version (SNOT-20 GAV) in chronic rhinosinusitis (CRS) patients require normative values measured in a comparison group taken from the normal population. These will make it possible to reach conclusions on correlations between scores and severity of symptoms and also on how close such patients' scores can get to those scores recorded in healthy subjects after surgical treatment.

PATIENTS AND METHODS

We collected SNOT-20 GAV data and data on the presence of CRS from 778 subjects via a web-based survey of employees of the University Hospital in Heidelberg. For comparison we used data collected before surgery and at 3 months and 1 year after surgery from 163 CRS patients who had undergone endonasal sinus surgery (ESS).

RESULTS

Gender and age had no clinically significant impact on the SNOT-20 GAV scores. We defined an assessment scale with four classes of symptom intensity. Surgically treated patients with CRS showed a persisting small disadvantage in the scales of the SNOT-20 GAV compared with the reference subgroup without CRS. When surgically treated CRS patients were compared with the entire reference group these disadvantages were only obvious in the Primary Nasal Symptoms (PNS) scale and not in the other scales measuring quality of life.

CONCLUSION

Patients with CRS benefit from ESS and subsequently reach scores similar to those recorded in the reference group. The newly developed four-level assessment scale is easy to use and gives the attending physician additional information about the severity of the patients' illness and its effects on their subjective wellbeing.

摘要

引言

使用慢性鼻-鼻窦炎(CRS)患者的中文版鼻鼻窦结局测试-20(SNOT-20 GAV)进行生活质量测量,需要在来自正常人群的对照组中测量规范值。这将有助于得出分数与症状严重程度之间的相关性结论,以及此类患者的分数在手术治疗后与健康受试者记录的分数接近程度的结论。

患者与方法

我们通过对海德堡大学医院员工的网络调查,收集了778名受试者的SNOT-20 GAV数据和CRS存在情况的数据。为了进行比较,我们使用了163例接受鼻内镜鼻窦手术(ESS)的CRS患者术前、术后3个月和1年收集的数据。

结果

性别和年龄对SNOT-20 GAV分数没有临床显著影响。我们定义了一个具有四类症状强度的评估量表。与无CRS的参考亚组相比,接受手术治疗的CRS患者在SNOT-20 GAV量表中仍存在轻微劣势。当将接受手术治疗的CRS患者与整个参考组进行比较时,这些劣势仅在主要鼻部症状(PNS)量表中明显,而在其他生活质量测量量表中不明显。

结论

CRS患者从ESS中获益,随后达到与参考组记录的分数相似的分数。新开发的四级评估量表易于使用,为主治医师提供了有关患者疾病严重程度及其对主观幸福感影响的额外信息。

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Dupilumab increases aspirin tolerance in NSAID-exacerbated respiratory disease.度普利尤单抗可提高 NSAID 加重的呼吸道疾病患者对阿司匹林的耐受性。
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