van Geffen E C G, van der Wal S W, van Hulten R, de Groot M C H, Egberts A C G, Heerdink E R
Science Shop for Medicines, Department of Pharmaceutical Sciences, Utrecht University, The Netherlands.
Eur J Clin Pharmacol. 2007 Dec;63(12):1193-9. doi: 10.1007/s00228-007-0375-4. Epub 2007 Sep 15.
To assess experiences related to antidepressant use reported to an internet-based medicine reporting system and to compare the nature of the side effects reported by patients with those reported by health care professionals (HCPs).
All reports submitted from May 2004 to May 2005 to an internet-based medicine reporting system in The Netherlands related to the use of antidepressants were analysed. Spontaneous reports of adverse drug reactions on antidepressants from HCPs received by The Netherlands Pharmacovigilance Centre Lareb from May 2004 to May 2005 were included for comparison.
Of the 2232 individuals who submitted a report to the internet-based medicine reporting system, 258 submitted a report on antidepressants. Of these, 92 individuals (36%) reported on effectiveness, 40 (16%) of whom reported on ineffectiveness, and 217 (84%) submitted a report on side effects, with 202 (78%) reporting a total of 630 side effects that were experienced as negative. Fourteen individuals (5%) reported a practical issue and four (2%) reported a reimbursement issue. Of all 630 side effects reported, 48% resulted in the patient discontinuing the antidepressant therapy; of these 29% did not inform their HCP. Of all the side effects reported, 52% were perceived as "very negative". In comparison to the side effects reported by HCPs, patients more often reported apathy, excessive sweating, ineffectiveness, somnolence, insomnia, sexual problems and weight increase.
Patients report the ineffectiveness and side effects of antidepressant therapy as negative and leading to discontinuation of the therapy. Patients and HCPs differ in the nature of the reported side effects. Patient experiences should be included in the evaluation of antidepressant treatment in clinical practice.
评估向一个基于互联网的药物报告系统报告的与使用抗抑郁药相关的经历，并比较患者报告的副作用性质与医疗保健专业人员（HCPs）报告的副作用性质。
分析了2004年5月至2005年5月提交至荷兰一个基于互联网的药物报告系统的所有与使用抗抑郁药相关的报告。纳入了荷兰药物警戒中心Lareb在2004年5月至2005年5月收到的HCPs关于抗抑郁药药物不良反应的自发报告用于比较。
在向基于互联网的药物报告系统提交报告的2232人中，258人提交了关于抗抑郁药的报告。其中，92人（36%）报告了疗效，40人（16%）报告无效，217人（84%）提交了关于副作用的报告，202人（78%）报告了总共630种被认为是负面的副作用。14人（5%）报告了实际问题，4人（2%）报告了报销问题。在报告的所有630种副作用中，48%导致患者停止抗抑郁治疗；其中29%未告知其HCP。在报告的所有副作用中，52%被认为“非常负面”。与HCPs报告的副作用相比，患者更常报告冷漠、多汗、无效、嗜睡、失眠、性问题和体重增加。
患者将抗抑郁治疗的无效和副作用报告为负面并导致治疗中断。患者和HCPs报告的副作用性质不同。患者的经历应纳入临床实践中抗抑郁治疗的评估。
