意义未明的单克隆丙种球蛋白病老年患者的骨密度较低。

Lower bone mineral density in geriatric patients with monoclonal gammopathy of undetermined significance.

作者信息

Dizdar Omer, Erman Mustafa, Cankurtaran Mustafa, Halil Meltem, Ulger Zekeriya, Yavuz Burcu Balam, Ariogul Servet, Pinar Asli, Harputluoglu Hakan, Kars Ayse, Celik Ismail

机构信息

Institute of Oncology, Department of Medical Oncology, Hacettepe University, Sihhiye, Ankara, Turkey.

出版信息

Ann Hematol. 2008 Jan;87(1):57-60. doi: 10.1007/s00277-007-0376-5. Epub 2007 Sep 14.

DOI:10.1007/s00277-007-0376-5

PMID:17874101

Abstract

The aim of this study was to investigate the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in a geriatric population in Turkey and compare bone mineral densities and related laboratory parameters of MGUS patients with those who do not have MGUS. Among 1,012 patients enrolled, monoclonal band was detected in serum samples of 22 patients (2.17%), most of which were IgG type. Further tests revealed multiple myeloma and lung carcinoma in two patients. The remaining 20 patients were diagnosed with MGUS (1.97%). The clinical and laboratory parameters of patients with and without MGUS were mostly comparable; however, bone mineral density measurements of patients with MGUS were significantly lower than those without MGUS (p = 0.007). We suggest evaluation of geriatric patients with MGUS for the presence of osteopenia/osteoporosis considering the high frequency observed in this study.

摘要

本研究的目的是调查土耳其老年人群中意义未明的单克隆丙种球蛋白病（MGUS）的患病率，并比较MGUS患者与非MGUS患者的骨密度及相关实验室参数。在纳入的1012例患者中，22例患者（2.17%）的血清样本中检测到单克隆条带，其中大部分为IgG型。进一步检查发现2例患者患有多发性骨髓瘤和肺癌。其余20例患者被诊断为MGUS（1.97%）。MGUS患者和非MGUS患者的临床和实验室参数大多具有可比性；然而，MGUS患者的骨密度测量值显著低于非MGUS患者（p = 0.007）。考虑到本研究中观察到的高频率，我们建议对患有MGUS的老年患者进行骨质减少/骨质疏松症的评估。