Cimino G, Avvisati G, Amadori S, Di Gregorio A O, Magliocca V, Petrucci M T, Sgadari C
Dipartimento di Biopatologia Umana, Università La Sapienza, Roma, Italia.
Nouv Rev Fr Hematol (1978). 1989;31(5):329-32.
Interleukin-1 (IL-1), Interleukin-2 (IL-2) and soluble receptors for IL-2 (sIL-2R) play a crucial role in the immune response. IL-2 in particular is implicated not only in T-cell proliferation but also in normal B-cell proliferation and differentiation and in the development of B and T cell malignancies. We have assayed the serum levels of IL-1, IL-2 and sIL-2R in 12 patients with monoclonal gammopathy of undetermined significance (MGUS) and 44 patients with multiple myeloma (MM). Sera collected from 40 healthy blood donors were used for normal values, and sera from 33 medical volunteers over 48 years of age (median age 52 years) for normal IL-2 values in the elderly. Mean IL-2 serum values were 6.50 U/ml in MGUS and 4.97 U/ml in MM patients. There was a statistical significant elevation of IL-2 levels is both MM and MGUS patients when compared to both normal controls (p less than 0.001, Wilcoxon two tailed test). A significant difference in IL-2 levels (p less than 0.025) was also observed between MGUS and MM patients. The levels of serum IL-1 and sIL-2R were normal both in MGUS and MM patients. In 24 MM patients where the dosage of serum beta-2-microglobulin was available, a significant difference (p less than 0.01) in serum IL-2 levels was found between patients with beta-2-microglobulin greater than 6 micrograms/ml and less than 6 micrograms/ml. Pathogenic mechanisms as well as their possible clinical significance are discussed.
白细胞介素-1（IL-1）、白细胞介素-2（IL-2）及IL-2可溶性受体（sIL-2R）在免疫反应中起关键作用。尤其是IL-2不仅与T细胞增殖有关，还与正常B细胞增殖和分化以及B和T细胞恶性肿瘤的发生发展有关。我们检测了12例意义未明的单克隆丙种球蛋白病（MGUS）患者和44例多发性骨髓瘤（MM）患者血清中IL-1、IL-2及sIL-2R的水平。从40名健康献血者采集的血清用作正常值对照，从33名年龄超过48岁（中位年龄52岁）的医学志愿者采集的血清用作老年人正常IL-2值对照。MGUS患者的平均血清IL-2值为6.50 U/ml，MM患者为4.97 U/ml。与正常对照组相比，MM和MGUS患者的IL-2水平均有统计学意义的升高（p小于0.001，Wilcoxon双尾检验）。MGUS和MM患者之间的IL-2水平也存在显著差异（p小于0.025）。MGUS和MM患者的血清IL-1和sIL-2R水平均正常。在24例可获得血清β2-微球蛋白剂量的MM患者中，β2-微球蛋白大于6微克/毫升和小于6微克/毫升的患者之间血清IL-2水平存在显著差异（p小于0.01）。本文讨论了其发病机制及其可能的临床意义。
