Hass Nicole, Schwarzenbacher Karin, Breer Heinz
University of Hohenheim, Institute of Physiology, Garbenstrasse 30, 70599, Stuttgart, Germany.
Histochem Cell Biol. 2007 Nov;128(5):457-71. doi: 10.1007/s00418-007-0325-3. Epub 2007 Sep 15.
In the gastrointestinal (GI) tract, a variety of digestive processes are continually adapted to the changing composition of ingested foods, which requires a precise chemosensory monitoring of luminal contents. Gustducin-expressing brush cells scattered throughout the GI mucosa are considered candidate sensory cells for accomplishing this task. In this study, we have investigated a large cluster of gustducin-positive cells which is located exactly at the boundary between the fundic and the oxyntic mucosa of the mouse stomach, at the so-called "limiting ridge". In close association with the candidate chemosensory cluster, we found two populations of enteroendocrine cells: one population containing the satiety regulating hormone ghrelin, the other population comprising serotonin-secreting enterochromaffin cells. The particular arrangement of gustducin-expressing cells and enteroendocrine cells at the limiting ridge suggests a direct interplay between these cell types with immediate implications, not only for digestive processes in the stomach, but also for parameters controlling the satiety status.
在胃肠道中，各种消化过程不断适应摄入食物成分的变化，这需要对管腔内容物进行精确的化学感应监测。散布于整个胃肠道黏膜的表达味觉传导素的刷状细胞被认为是完成这项任务的候选感觉细胞。在本研究中，我们调查了一大簇味觉传导素阳性细胞，其恰好位于小鼠胃底黏膜和泌酸黏膜之间的边界处，即所谓的“界限嵴”。与候选化学感应簇紧密相连，我们发现了两类肠内分泌细胞：一类含有调节饱腹感的激素胃饥饿素，另一类是分泌5-羟色胺的肠嗜铬细胞。界限嵴处表达味觉传导素的细胞与肠内分泌细胞的特殊排列表明，这些细胞类型之间存在直接相互作用，这不仅对胃内的消化过程有直接影响，而且对控制饱腹感状态的参数也有直接影响。
