与人类免疫缺陷病毒1型逆转录酶中K70G和M184V突变相关的新型耐药模式。
Novel drug resistance pattern associated with the mutations K70G and M184V in human immunodeficiency virus type 1 reverse transcriptase.
作者信息
Bradshaw D, Malik S, Booth C, Van Houtte M, Pattery T, Waters A, Ainsworth J, Geretti A M
机构信息
Department of Virology, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2007 Dec;51(12):4489-91. doi: 10.1128/AAC.00687-07. Epub 2007 Sep 17.
Abstract
We describe an unusual pathway of human immunodeficiency virus type 1 reverse transcriptase resistance during therapy with tenofovir-emtricitabine, characterized initially by the mutations K70E and M184V and later by K70G and M184V, with the two mutations coexisting on the same viral genome. Phenotypic resistance to lamivudine, emtricitabine, abacavir, didanosine, and tenofovir was observed, whereas susceptibility to zidovudine and stavudine was preserved.
摘要
我们描述了在使用替诺福韦-恩曲他滨治疗期间，人类免疫缺陷病毒1型逆转录酶产生耐药性的一种不寻常途径，其最初特征为K70E和M184V突变，随后为K70G和M184V突变，这两种突变共存于同一病毒基因组上。观察到对拉米夫定、恩曲他滨、阿巴卡韦、去羟肌苷和替诺福韦具有表型耐药性，而对齐多夫定和司他夫定仍保持敏感性。
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