Hosaka Masayoshi, Ebina Yasuhiko, Moriwaki Masashi, Hara Yoko, Araki Naoto, Todo Yukiharu, Takeda Mahito, Watari Hidemichi, Sakuragi Noriaki
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine.
Gan To Kagaku Ryoho. 2007 Sep;34(9):1505-8.
The standard chemotherapy for ovarian carcinoma is paclitaxel and carboplatin concomitant therapy. This combination is so frequently administered that a carboplatin-associated hypersensitivity reaction may occur after long-term treatment. Recently, we experienced carboplatin-associated hypersensitivity reactions in three cases. They showed symptoms of tachycardia, chest tightness, and dyspnea. We report these cases that could be readministered platinum agent using the cisplatin desensitization method. This method was relatively safe and successful for patients with platinum-sensitive disease.
卵巢癌的标准化疗方案是紫杉醇与卡铂联合治疗。这种联合用药非常频繁，以至于长期治疗后可能会发生卡铂相关的过敏反应。最近，我们遇到了3例卡铂相关的过敏反应。患者表现出心动过速、胸闷和呼吸困难的症状。我们报告了这些可采用顺铂脱敏法重新给予铂类药物的病例。该方法对铂类敏感疾病患者相对安全且有效。
