Yoshida Shigeto, Shimada Yohei, Watanabe Hiroyuki
Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University.
Nihon Rinsho. 2007 Sep;65(9):1715-26.
Malaria is a devastating disease that kills millions of people every year, yet there has been little progress in controlling this disease. Mosquitoes are obligatory vectors for the disease and this part of the parasite cycle represents a potential weak link in transmission. Therefore, control of parasite development in the mosquito has considerable promise as a new approach in the fight against malaria. In recent year, methods for the genetic modification of mosquitoes have been developed, and effector genes whose products interfere with Plasmodium development in the mosquito are beginning to be identified. Here we review strategies to alter mosquito vector competence and consider issues related to translating this knowledge to field applications.
疟疾是一种每年导致数百万人死亡的毁灭性疾病，但在控制这种疾病方面进展甚微。蚊子是该疾病的 obligatory 传播媒介，而寄生虫生命周期的这一部分是传播过程中一个潜在的薄弱环节。因此，控制疟原虫在蚊子体内的发育作为对抗疟疾的一种新方法具有很大的前景。近年来，已开发出蚊子基因改造方法，其产物干扰疟原虫在蚊子体内发育的效应基因也开始被识别。在此，我们综述改变蚊子传播能力的策略，并考虑将这些知识转化为实际应用所涉及的问题。
