Bednarek-Tupikowska Grazyna, Tupikowski Krzysztof, Bohdanowicz-Pawlak Anna, Bidzińska Bozena, Szymczak Jadwiga, Filus Alicja, Kuliczkowska Justyna, Milewicz Andrzej
Katedra i Klinika Endokrynologii i Diabetologii AM we Wrocławiu.
Pol Merkur Lekarski. 2005 Feb;18(104):189-91.
The aim of study was to evaluate the influence of sex hormones: estradiol (E), follicle-stimulating hormone (FSH), progesterone (P), testosterone (T), dehydroepiandrosterone (DHEA-S) and cortisol (F) on the serum homocysteine concentration (HCY) in 40 premenopausal (group M) and 80 postmenopausal (group K) women. The influence of E2 therapy (ET) on the serum HCY level in the women with surgical menopause was also estimated. The plasma HCY concentration in the group M was significantly higher that in group K. After ET serum HCY level decreased significantly. No correlations were found between serum HCY and E2 concentrations in the all groups. No correlations were observed between HCY and FSH, P, T and F concentrations in pre-and postmenopausal groups. There was a significant negative correlation between serum HCY and DHEA-S concentration in group K. This result may indicate, that high level of DHEA decreases HCY concentration. There was no correlation in group M, where the mean concentration of DHEA was lower than in group K. The results of study indicate, that menopause increases and ET decreases plasma HCY concentration. DHEA-S may inhibit plasma HCY concentration in premenopausal women. More studies are needed to elucidate these hypotheses.
雌二醇（E）、促卵泡激素（FSH）、孕酮（P）、睾酮（T）、脱氢表雄酮（DHEA-S）和皮质醇（F）对40名绝经前女性（M组）和80名绝经后女性（K组）血清同型半胱氨酸浓度（HCY）的影响。同时还评估了雌激素替代疗法（ET）对手术绝经女性血清HCY水平的影响。M组血浆HCY浓度显著高于K组。ET治疗后血清HCY水平显著下降。所有组中血清HCY与E2浓度之间均未发现相关性。绝经前和绝经后组中HCY与FSH、P、T和F浓度之间均未观察到相关性。K组中血清HCY与DHEA-S浓度之间存在显著负相关。这一结果可能表明，高水平的DHEA会降低HCY浓度。M组中未发现相关性，M组中DHEA的平均浓度低于K组。研究结果表明，绝经会增加而ET会降低血浆HCY浓度。DHEA-S可能会抑制绝经前女性的血浆HCY浓度。需要更多研究来阐明这些假设。
