Ghorbanihaghjo Amir, Javadzadeh Alireza, Argani Hassan, Nezami Nariman, Rashtchizadeh Nadereh, Rafeey Mandana, Rohbaninoubar Mohammad, Rahimi-Ardabili Babak
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mol Vis. 2008 Sep 15;14:1692-7.
Elevated levels of lipoprotein(a) [Lp(a)] and homocysteine (Hcy) have been implicated as risk factors for vascular diseases. The study was performed to explore the possible relationship between retinal arteriosclerosis and serum Lp(a) and Hcy levels.
Study subjects consisted of 80 nonsmoking male patients with retinal arteriosclerosis and 54 healthy nonsmoker males as controls. Retinal arteriosclerosis was graded according to the Scheie classification. Serum levels of lipids, lipoproteins, Lp(a), and Hcy were measured by standard methods.
The serum level of Hcy was higher in patients (24.2+/-8.1 micromol/l) than controls (10.5+/-4.1 micromol/l); p<0.01. Serum levels of Lp(a) in patients (47.9+/-33.1 mg/dl) was also higher than controls (11.7+/-7.6 mg/dl); p<0.01. There was a significant direct linear correlation between the degree of retinal arteriosclerosis and Lp(a) level (r=0.61, p<0.01), the degree of retinal arteriosclerosis and Hcy level (r=0.72, p<0.01), and also between Lp(a) and Hcy levels (r=0.67, p<0.01).
The association between retinal arteriosclerosis and serum Lp(a) and Hcy levels suggests that Lp(a) as well as Hcy could play a role in the development of retinal arteriosclerosis.
脂蛋白(a)[Lp(a)]和同型半胱氨酸(Hcy)水平升高被认为是血管疾病的危险因素。本研究旨在探讨视网膜动脉硬化与血清Lp(a)和Hcy水平之间的可能关系。
研究对象包括80例患有视网膜动脉硬化的不吸烟男性患者和54例健康不吸烟男性作为对照。视网膜动脉硬化根据Scheie分类法进行分级。采用标准方法测量血脂、脂蛋白、Lp(a)和Hcy的血清水平。
患者的血清Hcy水平(24.2±8.1微摩尔/升)高于对照组(10.5±4.1微摩尔/升)；p<0.01。患者的血清Lp(a)水平(47.9±33.1毫克/分升)也高于对照组(11.7±7.6毫克/分升)；p<0.01。视网膜动脉硬化程度与Lp(a)水平之间存在显著的直接线性相关性(r=0.61，p<0.01)，视网膜动脉硬化程度与Hcy水平之间存在显著的直接线性相关性(r=0.72，p<0.01)，Lp(a)和Hcy水平之间也存在显著的直接线性相关性(r=0.67，p<0.01)。
视网膜动脉硬化与血清Lp(a)和Hcy水平之间的关联表明，Lp(a)以及Hcy可能在视网膜动脉硬化的发展中起作用。
