Akula Kiran Kumar, Dhir Ashish, Kulkarni S K
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India.
Indian J Exp Biol. 2007 Aug;45(8):720-5.
Cefazolin injection (3000 mg/kg, i.v.) in mice showed several behavioral excitations such as wild running, jumping, rolling, and finally undergoing severe convulsions followed by death. It's lower doses (500-2000 mg/kg, i.v.) were unable to produce any convulsions or behavioral excitations in mice. However, cefazolin (500 or 1000 mg/kg, i.v.) when administered before different doses of pentylenetetrazol (PTZ; 40 or 60 mg/kg, i.p.) or picrotoxin (PTX; 4 or 8 mg/kg, i.p.), it produced severe tonic-clonic convulsions in mice. The convulsions or behavioral excitations produced by 3000 mg/kg, i.v. cefazolin was also reversed by different doses of diazepam (0.5-2 mg/kg, i.p.) further proving the GABAergic modulatory effect of cefazolin. The results conclude the pro-convulsant action of cefazolin on PTZ- or PTX-induced convulsions, and further confirm the clinical reports.
在小鼠中，静脉注射头孢唑林（3000毫克/千克）会出现多种行为兴奋症状，如疯狂奔跑、跳跃、翻滚，最终发生严重惊厥并导致死亡。其较低剂量（500 - 2000毫克/千克，静脉注射）在小鼠中不会引起任何惊厥或行为兴奋。然而，当在不同剂量的戊四氮（PTZ；40或60毫克/千克，腹腔注射）或苦味毒（PTX；4或8毫克/千克，腹腔注射）之前静脉注射头孢唑林（500或1000毫克/千克）时，会使小鼠产生严重的强直性阵挛性惊厥。静脉注射3000毫克/千克头孢唑林所引起的惊厥或行为兴奋也可被不同剂量的地西泮（0.5 - 2毫克/千克，腹腔注射）逆转，这进一步证明了头孢唑林的GABA能调节作用。结果表明头孢唑林对PTZ或PTX诱导的惊厥具有促惊厥作用，并进一步证实了临床报告。
