Le Ngoc-Anh, Walter Mary F
Emory Lipid Research Laboratory, Atlanta Veterans' Affairs Medical Center, 1670 Clairemont Road, Room 4A187, Decatur, GA 30033, USA.
Curr Atheroscler Rep. 2007 Aug;9(2):110-5. doi: 10.1007/s11883-007-0006-7.
Atherosclerosis is a chronic disease associated with accumulation of lipids in lesions along blood vessels, leading to the occlusion of blood flow. Much of the focus has been on the role of low-density lipoprotein (LDL), and of oxidatively modified LDL, in the initiation and progression of this disease. LDL is in fact a metabolic end-product of the triglyceride-rich lipoproteins (ie, very-low density lipoproteins). Over the years, univariate analyses have implicated triglycerides as a contributor in atherosclerosis. However, depending on the studies, the significance of this relationship is either reduced or nullified when other co-variates are taken into account. This review summarizes more recent data that support the role of triglyceride-rich lipoproteins in the atherosclerotic process, both in the fasted as well as in the postprandial state.
动脉粥样硬化是一种慢性疾病，与血管病变处脂质积聚有关，可导致血流阻塞。人们大多关注低密度脂蛋白（LDL）以及氧化修饰的LDL在该疾病发生和发展中的作用。事实上，LDL是富含甘油三酯的脂蛋白（即极低密度脂蛋白）的代谢终产物。多年来，单变量分析表明甘油三酯是动脉粥样硬化的一个促成因素。然而，根据不同研究，当考虑其他协变量时，这种关系的重要性要么降低，要么消失。本综述总结了更多最新数据，这些数据支持富含甘油三酯的脂蛋白在空腹和餐后状态下的动脉粥样硬化过程中的作用。
