Laenkholm Anne-Vibeke, Hoffmann Jack, Rank Fritz E
Odense Universitetshospital, Afdeling for Klinisk Patologi, Hørsholm Sygehus, Brystkirurgisk Klinik.
Ugeskr Laeger. 2007 Sep 10;169(37):3087-90.
Ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS) represent a proliferation of malignant epithelial cells within the ducts of the breast without invasion through the basement membrane. It is assumed that all invasive carcinomas of the breast are preceded by DCIS or LCIS. However, it is not known what proportion of DCIS or LCIS--if left untreated--will progress to invasive carcinoma. Standard treatment for DCIS is breast-conserving surgery with free margins and radiation therapy. LCIS is usually treated by observation alone.
导管原位癌（DCIS）和小叶原位癌（LCIS）表现为乳腺导管内恶性上皮细胞的增殖，且未突破基底膜发生浸润。一般认为，所有乳腺浸润性癌之前都有DCIS或LCIS。然而，尚不清楚DCIS或LCIS（若不治疗）会进展为浸润性癌的比例是多少。DCIS的标准治疗方法是行切缘阴性的保乳手术及放射治疗。LCIS通常仅通过观察进行治疗。
