产超广谱β-内酰胺酶SHV-12型肠杆菌科细菌在坦桑尼亚儿童中引起败血症：抗菌药物耐药性水平转移的载体
Extended-spectrum beta-lactamase-type SHV-12-producing Enterobacteriaceae causing septicemia in Tanzanian children: vectors for horizontal transfer of antimicrobial resistance.
作者信息
Tellevik Marit Gjerde, Sollid Johanna Ericson, Blomberg Bjørn, Jureen Roland, Urassa Willy K, Langeland Nina
机构信息
Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
出版信息
Diagn Microbiol Infect Dis. 2007 Nov;59(3):351-4. doi: 10.1016/j.diagmicrobio.2007.06.015. Epub 2007 Sep 18.
Septicemia caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae was associated with high mortality in Tanzanian children. Conjugation experiments on the SHV-12-producing Enterobacteriaceae isolates showed that ESBL-encoding genes were transferred on large plasmids together with genes encoding resistance to aminoglycosides, resistance to ceftazidime, gentamicin, doxycycline, trimethoprim-sulfamethoxazole, and chloramphenicol.
由产超广谱β-内酰胺酶（ESBL）的肠杆菌科细菌引起的败血症与坦桑尼亚儿童的高死亡率相关。对产SHV-12的肠杆菌科细菌分离株进行的接合实验表明，ESBL编码基因与编码对氨基糖苷类抗生素耐药、对头孢他啶耐药、对庆大霉素耐药、对多西环素耐药、对甲氧苄啶-磺胺甲恶唑耐药以及对氯霉素耐药的基因一起在大质粒上转移。
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