Patel Haresh M, Suhagia Bhanubhai N, Shah Shailesh A, Rathod Ishwar Sinh, Parmar Vijay K
Department of Quality Assurance, L. M. College of Pharmacy, Navrangpura, Ahmedabad-380009 India.
Acta Pharm. 2007 Sep;57(3):351-9. doi: 10.2478/v10007-007-0028-2.
The binary system of etoricoxib with beta-cyklodextrin (beta-CD) was prepared by the kneading method. Drug-cyclodextrin interactions in solution were investigated by the phase solubility analysis. Differential scanning calorimetry, infrared spectroscopy, powder X-ray diffractometry and microscopic study were used to characterize the solid state of all binary systems, whereas their dissolution properties were evaluated according to the USP XXIII paddle method. The results indicate partial interaction of the drug with beta-CD in the physical mixture and complete interaction in the kneaded complex. The dissolution of etoricoxib was notably increased as compared to pure drug as well as its physical mixture. The complex showed more than 75% drug released in 30 min.
依托考昔与β-环糊精（β-CD）的二元体系采用捏合法制得。通过相溶解度分析研究溶液中药物与环糊精的相互作用。采用差示扫描量热法、红外光谱法、粉末X射线衍射法和显微镜研究对所有二元体系的固态进行表征，而其溶出特性则根据美国药典XXIII桨法进行评估。结果表明，在物理混合物中药物与β-CD存在部分相互作用，而在捏合复合物中存在完全相互作用。与纯药物及其物理混合物相比，依托考昔的溶出度显著提高。该复合物在30分钟内药物释放量超过75%。
