Shah Manali, Karekar Poonam, Sancheti Pankajkumar, Vyas Vikrant, Pore Yogesh
Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra, India.
Drug Dev Ind Pharm. 2009 Jan;35(1):118-29. doi: 10.1080/03639040802220292.
The effect of polyvinyl pyrrolidone (PVP) K30 and/or L-arginine on etoricoxib-HPbetaCD complex was investigated. The phase solubility profiles were classified as A(L)-type, both in absence or presence of auxiliary substances used. The apparent stability constant (K(c)) of binary complex obtained at room temperature, 371.80 +/- 2.61 M(-1), was decreased with the addition of PVP and arginine indicating no benefit of addition of auxiliary substances to promote higher complexation efficiency. Therefore, solid etoricoxib-HPbetaCD binary systems were prepared and characterized by proton nuclear magnetic resonance spectroscopy (1HNMR), X-ray powder diffractometry, Fourier transformation-infrared spectroscopy, and dissolution studies. Among all binary systems, a lyophilized product showed superior performance in enhancing dissolution of etoricoxib.
研究了聚乙烯吡咯烷酮（PVP）K30和/或L-精氨酸对依托考昔-HPβCD复合物的影响。无论是否存在所用辅助物质，相溶解度曲线均归类为A（L）型。在室温下获得的二元复合物的表观稳定常数（Kc）为371.80±2.61 M-1，随着PVP和精氨酸的加入而降低，这表明添加辅助物质无助于提高络合效率。因此，制备了固体依托考昔-HPβCD二元体系，并通过质子核磁共振光谱（1HNMR）、X射线粉末衍射、傅里叶变换红外光谱和溶出度研究对其进行了表征。在所有二元体系中，冻干产品在提高依托考昔溶出度方面表现出优异性能。
