Neto Domingos, Lambaz Rita, Tavares João Eduardo
Centro Regional de Alcoologia do Sul, CRAS, Parque de Saúde de Lisboa, Av. do Brasil, 53 A. 1749-006 Lisbon, Portugal.
Alcohol Alcohol. 2007 Nov-Dec;42(6):604-9. doi: 10.1093/alcalc/agm062. Epub 2007 Sep 18.
To delineate the features of treatment compliance which predicted outcome during aftercare treatment in a series of patients that completed an inpatient program at the Lisbon Regional Alcohology Centre (CRAS).
Seventy-four alcohol dependent patients, sequentially admitted to the inpatient treatment of CRAS, were followed over 6 months after discharge. This study focused on the predictive value of the aftercare therapies, which included: attending Alcoholics Anonymous (AA) meetings, attending aftercare groups (AG), attending outpatient consultations with the medical assistant. Disulfiram was prescribed to 83.3% of the patients. At the end of the 6-months follow-up period, the patients and their 'significant others' (co-responsible persons) were interviewed on the telephone by an independent interviewer. The data collected for analysis consists of information from the interviews, and also of data from the patient clinical files.
Survival analysis revealed that, after 6 months of follow-up, 39.2% of the patients had attained total abstinence of alcohol ingestion; 71% of the relapses on alcohol consumption occurred within the first 3 months. The median number of days taking disulfiram was significantly related to the number of days of abstinence. Demographic variables, pre-treatment variables, attendance at AA meetings, AGs and outpatient appointments were not significant predictors of outcome.
Consistently taking disulfiram is associated with good outcome, but this may reflect commitment to abstinence as well as a treatment effect.
在里斯本地区酒精学中心（CRAS）完成住院治疗项目的一系列患者中，描绘预测后期护理治疗结果的治疗依从性特征。
对74名先后入住CRAS接受住院治疗的酒精依赖患者出院后进行了6个月的随访。本研究聚焦于后期护理治疗的预测价值，其中包括：参加戒酒互助会（AA）会议、参加后期护理小组（AG）、与医疗助理进行门诊咨询。83.3%的患者被开了双硫仑。在6个月随访期结束时，由一名独立访谈者通过电话对患者及其“重要他人”（共同责任人）进行访谈。收集用于分析的数据包括访谈信息以及患者临床档案中的数据。
生存分析显示，随访6个月后，39.2%的患者实现了完全戒酒；71%的酒精复饮发生在头3个月内。服用双硫仑的天数中位数与戒酒天数显著相关。人口统计学变量、治疗前变量、参加AA会议、AG和门诊预约并不是结果的显著预测因素。
持续服用双硫仑与良好的治疗结果相关，但这可能既反映了对戒酒的坚持，也反映了治疗效果。
