The actions of a conformationally restricted analogue of aspartic acid on mammalian spinal neurones.
作者信息
Corden M, Curry K, McLennan H
机构信息
Department of Physiology, University of British Columbia, Vancouver, Canada.
出版信息
Neurosci Lett. 1991 Oct 28;132(1):37-8. doi: 10.1016/0304-3940(91)90427-u.
PMID:1787916
Abstract
The effects of the 4 stereoisomers of 1-aminocyclopentane-1,2-dicarboxylic acid (CPA), a conformationally restricted analogue of aspartic acid, have been examined on spinal dorsal horn neurones of the rat in vivo. Unlike the corresponding 1,3-dicarboxylate compounds which are glutamate analogues and markedly excitatory, the CPA isomers had no evident excitatory actions of their own. Three were weak and non-specific antagonists of other amino acid-induced excitations, while the (+)-trans isomer had a slight potentiating effect.
摘要
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