氯胺酮光学异构体对氨基酸和乙酰胆碱激发猫和大鼠脊髓神经元的影响。
Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine.
作者信息
Lodge D, Anis N A, Burton N R
出版信息
Neurosci Lett. 1982 Apr 26;29(3):281-6. doi: 10.1016/0304-3940(82)90330-5.
PMID:7048142
Abstract
The (+) isomer of ketamine was approximately 3 and 1.5 times as potent as the (-) isomer in reducing excitation of rat and cat Renshaw cells by N-methylaspartate (NMA) and acetylcholine (ACh) respectively. The potency ratio of the two isomers of ketamine as NMA antagonists was similar to that obtained in anaesthetic and analgesic tests [16, 19, 25].
摘要
氯胺酮的（+）异构体在分别降低N-甲基天冬氨酸（NMA）和乙酰胆碱（ACh）对大鼠和猫Renshaw细胞的兴奋作用方面，效力约为（-）异构体的3倍和1.5倍。氯胺酮两种异构体作为NMA拮抗剂的效价比与在麻醉和镇痛试验中得到的结果相似[16,19,25]。
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