芳香族氨基酸、戊四氮和育亨宾对大鼠脑中异吲哚酮和刺蒺藜素活性的影响。

Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain.

作者信息

Bhattacharya S K, Clow A, Przyborowska A, Halket J, Glover V, Sandler M

机构信息

Department of Chemical Pathology, Queen Charlottes's and Chelsea Hospital, London, U.K.

出版信息

Neurosci Lett. 1991 Oct 28;132(1):44-6. doi: 10.1016/0304-3940(91)90429-w.

DOI:10.1016/0304-3940(91)90429-w

PMID:1787917

Abstract

The effects of i.p. injection of 3 aromatic amino acids and two anxiogenic agents on rat brain isatin concentration and tribulin (endogenous monoamine oxidase inhibitor) activity were investigated. Isatin levels were significantly increased by pentylenetetrazole, confirming the link with 'anxiety', but were unaffected by the other compounds. In contrast, tribulin activity was significantly increased by phenylalanine and tryptophan as well as by both pentylenetetrazole and yohimbine. Whilst these findings shed no light on the mode of synthesis of isatin, they clearly demonstrate the existence of rat brain monoamine oxidase inhibitory activity that is different from it.

摘要

研究了腹腔注射3种芳香族氨基酸和两种致焦虑剂对大鼠脑异吲哚酮浓度和三溴林（内源性单胺氧化酶抑制剂）活性的影响。戊四氮显著提高了异吲哚酮水平，证实了其与“焦虑”的联系，但其他化合物对其无影响。相比之下，苯丙氨酸、色氨酸以及戊四氮和育亨宾均显著提高了三溴林活性。虽然这些发现未能揭示异吲哚酮的合成方式，但它们清楚地证明了大鼠脑内存在不同于异吲哚酮的单胺氧化酶抑制活性。