Kuhn Joseph A, Nochumson Joshua
Department of Surgery, Baylor University, Dallas, TX 75246, USA.
J Surg Oncol. 2007 Sep 15;96(4):290-6. doi: 10.1002/jso.20870.
Surgeons introduced the hand-held gamma detection probe in combination with tumor-directed monoclonal antibodies in patients with colorectal cancer. The clinicians conducted innovative research involving antibody chemistry and variation as well as radioactive dosimetry and decay. The results of these studies represented an era when surgeons began reporting on specific lesion detection and the impact of the antibody administration on the management of the patient. The summary of the important early trials involving monoclonal antibodies and probe scintimetry provides a valuable look into the early development of the antibody technology and a glimpse of potential future applications using the gamma detection probe.
外科医生将手持式γ探测探头与针对肿瘤的单克隆抗体联合应用于结直肠癌患者。临床医生开展了涉及抗体化学与变异以及放射性剂量测定和衰变的创新性研究。这些研究结果代表了一个时代，外科医生开始报告特定病变的检测情况以及抗体给药对患者治疗的影响。涉及单克隆抗体和探头闪烁扫描法的重要早期试验总结，为抗体技术的早期发展提供了有价值的见解，并让我们瞥见了使用γ探测探头的潜在未来应用。
