Mion François, Gincul Rodica, Roman Sabine, Beorchia Sylvain, Hedelius Frank, Claudel Nicolas, Bory Roger-Michel, Malvoisin Etienne, Trepo Frédérique, Napoleon Bertrand
Hospices Civils de Lyon, Fédération des Spécialités Digestives, Hôpital E. Herriot, Lyon, France.
Obes Surg. 2007 Jun;17(6):764-9. doi: 10.1007/s11695-007-9141-z.
Intragastric balloons have been proposed to induce body weight loss in obese subjects. Most studies were performed using liquid-filled balloons. Air-filled balloons may increase digestive tolerance. Our goal was to study the tolerance and efficacy of a new air-filled intragastric balloon in nonmorbidly obese patients.
32 patients were included, with a mean BMI of 35.0 (range 30.1-40.0). The balloon was inserted under general anaesthesia, inflated with 800 ml of air, and removed 4 months later. Tolerance and body weight were monitored until 12 months after removal. Ghrelin levels were measured before balloon insertion, 1 and 4 weeks after, and before removal.
Weight loss was significant at 1, 2 and 4 months after balloon insertion (6, 7 and 10 kg, respectively, P<0.001). Early removal of the balloon occurred in 3 cases. 28 patients were contacted 12 months after balloon removal: 2 had undergone gastric banding; among the 26 remaining, the mean weight loss was 7 kg. 9 patients (30%) remained with a weight loss >10%, and satisfaction with the method was 87% for these 9 patients, and 22% for the other patients who had weight loss <10% (P<0.04). Fasting plasma ghrelin levels increased at week 1 and 4 after balloon insertion, and decreased at week 16 (P<0.001). CONCLUSIONS. The air-filled intragastric balloon was safe. Its effect on weight loss appeared equivalent to other balloons. 12 months after balloon removal, 30% of the patients maintained a weight loss >10%.
胃内球囊已被用于诱导肥胖受试者体重减轻。大多数研究使用的是充液球囊。充气球囊可能会提高消化耐受性。我们的目标是研究一种新型充气胃内球囊在非病态肥胖患者中的耐受性和疗效。
纳入32例患者，平均体重指数（BMI）为35.0（范围30.1 - 40.0）。球囊在全身麻醉下插入，充入800毫升空气，并在4个月后取出。监测耐受性和体重直至取出后12个月。在球囊插入前、插入后1周和4周以及取出前测量胃饥饿素水平。
球囊插入后1、2和4个月体重显著减轻（分别为6、7和10千克，P<0.001）。3例患者提前取出球囊。在球囊取出12个月后联系了28例患者：2例接受了胃束带手术；在其余26例中，平均体重减轻7千克。9例患者（30%）体重减轻超过10%，这9例患者对该方法的满意度为87%，体重减轻低于10%的其他患者满意度为22%（P<0.04）。空腹血浆胃饥饿素水平在球囊插入后第1周和第4周升高，在第16周下降（P<0.001）。结论：充气胃内球囊是安全的。其对体重减轻的效果似乎与其他球囊相当。球囊取出12个月后，30%的患者体重减轻超过10%。
