Dixon John B, Strauss Boyd J G, Laurie Cheryl, O'Brien Paul E
Centre for Obesity Research and Education (CORE), Monash University, Melbourne, Victoria, Australia.
Obes Surg. 2007 Jun;17(6):770-7. doi: 10.1007/s11695-007-9142-y.
There is great need for simple anthropometric measures that predict risk. The authors explored the relationship between body composition measures and features of the metabolic syndrome (MtS) in women aged between 20 and 50 years with class I obesity.
This is a cross-sectional study of 49 obese (BMI 30-35) women recruited into a weight management randomized trial. An analysis was conducted of the baseline weight, anthropometric measures, skin-fold thickness, bioelectrical impedance, whole body dual-energy x-ray absorptiometry (DEXA), and their relationships with the features of the MtS.
All women but one (n=48) had a population risk waist circumference of >88 cm. 16 of the 49 (33%) fulfilled the criteria of the metabolic syndrome. Simple anthropometric measures provided the strongest correlations with the presence of the MtS. Cut-off values were selected using receiver operator characteristics. Waist circumference of >100 cm and hip circumference <115cm was associated with odds ratios of 5.2 (95% CI, 1.4-20) and 12.3 (95% CI, 3.0-51) respectively for the MtS. Regional DEXA analysis showed that lower leg fat mass rather than fat-free mass was associated with the MtS. The dyslipidemia of the MtS was associated with a lower leg fat mass, while higher HbAlc levels and HOMA, an indirect measure of insulin resistance, were seen with increased trunk fat. Percentage fat as measured by skin-fold thickness and bioelectrical impedance were not related to any features. Women with the metabolic syndrome were found to have lower bone mineral content as measured by DEXA.
Weight distribution is highly predictive of metabolic risk. Smaller hip and larger waist circumference provided independent effect. BMI adjusted anthropometric measures may be of value.
非常需要能够预测风险的简单人体测量方法。作者探讨了20至50岁I级肥胖女性的身体成分测量指标与代谢综合征（MtS）特征之间的关系。
这是一项横断面研究，对49名肥胖（BMI 30 - 35）女性进行了体重管理随机试验。对基线体重、人体测量指标、皮褶厚度、生物电阻抗、全身双能X线吸收法（DEXA）及其与MtS特征的关系进行了分析。
除一名女性外，所有女性（n = 48）的人群风险腰围均>88 cm。49名女性中有16名（33%）符合代谢综合征标准。简单的人体测量指标与MtS的存在具有最强的相关性。使用受试者工作特征曲线选择临界值。腰围>100 cm和臀围<115 cm与MtS的比值比分别为5.2（95% CI，1.4 - 20）和12.3（95% CI，3.0 - 51）。区域DEXA分析表明，小腿脂肪量而非去脂体重与MtS相关。MtS的血脂异常与小腿脂肪量相关，而较高的糖化血红蛋白水平和HOMA（胰岛素抵抗的间接测量指标）与躯干脂肪增加有关。通过皮褶厚度和生物电阻抗测量的体脂百分比与任何特征均无关联。发现患有代谢综合征的女性通过DEXA测量的骨矿物质含量较低。
体重分布对代谢风险具有高度预测性。较小的臀围和较大的腰围具有独立影响。调整BMI后的人体测量指标可能具有价值。
