Zhou Jianhua, Chen J K, Zhang Yuwen
Department of Mechanical and Aerospace Engineering, University of Missouri-Columbia, Columbia, MO 6521, USA.
Mol Cell Biomech. 2007 Mar;4(1):27-39.
A bioheat transfer approach is proposed to study thermal damage in biological tissues caused by laser radiation. The laser light propagation in the tissue is first solved by using a robust seven-flux model in cylindrical coordinate system. The resulting spatial distribution of the absorbed laser energy is incorporated into the bioheat transfer equation for solving temperature response. Thermal damage to the tissue is assessed by the extent of denatured protein using a rate process equation. It is found that for the tissue studied, a significant protein denaturation process would take place when temperature exceeds about 53 degrees C. The effects of laser power, exposure time and beam size as well as the tissue absorption and scattering coefficients on the thermal damage process are examined and discussed. The laser conditions that cause irreversible damage to the tissue are also identified.
提出了一种生物热传递方法来研究激光辐射对生物组织造成的热损伤。首先，在柱坐标系中使用稳健的七通量模型求解激光在组织中的传播。将吸收的激光能量的空间分布结果代入生物热传递方程以求解温度响应。使用速率过程方程通过变性蛋白质的程度来评估组织的热损伤。研究发现，对于所研究的组织，当温度超过约53摄氏度时会发生显著的蛋白质变性过程。研究并讨论了激光功率、照射时间、光束尺寸以及组织吸收和散射系数对热损伤过程的影响。还确定了对组织造成不可逆损伤的激光条件。
