Jovanovic Kevin, Taylor Hugh S
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8063, USA.
J Reprod Med. 2007 Aug;52(8):667-9.
To determined the dose response of insulin resistance (IR) to estrogen in individual patients.
Eighteen subjects meeting inclusion criteria were enrolled, and 9 completed the study. Each subject was treated for 3 months with 0.3, 0.625 and 1.25 mg of conjugated equine estrogens (CEE) in random order, for a total of 9 months of treatment. Fasting serum insulin and glucose levels were obtained.
The fasting glucose/insulin ratio and quantitative insulin-sensitivity check index (QUICKI) were calculated. No significant change was noted in either parameter with any dose of CEE in a single subject.
This was the first study to examine the dose response of IR to estrogen using paired measurements from individuals. IR does not vary in individuals when doses of estrogen are altered.
确定个体患者中胰岛素抵抗（IR）对雌激素的剂量反应。
招募了18名符合纳入标准的受试者，其中9名完成了研究。每位受试者按随机顺序接受0.3、0.625和1.25毫克结合马雌激素（CEE）治疗3个月，总共治疗9个月。获取空腹血清胰岛素和血糖水平。
计算空腹血糖/胰岛素比值和定量胰岛素敏感性检查指数（QUICKI）。在单个受试者中，任何剂量的CEE均未使这两个参数发生显著变化。
这是第一项使用个体配对测量来研究IR对雌激素剂量反应的研究。当改变雌激素剂量时，个体的IR没有变化。
